{"id":27368,"date":"2024-09-11T17:22:55","date_gmt":"2024-09-11T15:22:55","guid":{"rendered":"https:\/\/eyelaser.at\/pack-crosslinking-for-corneal-infections\/"},"modified":"2025-02-10T15:56:54","modified_gmt":"2025-02-10T14:56:54","slug":"pack-crosslinking-for-corneal-infections","status":"publish","type":"post","link":"https:\/\/eyelaser.at\/en\/pack-crosslinking-for-corneal-infections\/","title":{"rendered":"PACK crosslinking for corneal infections"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Crosslinking was originally developed for the treatment of keratoconus.<br \/>\nThe areas of application have been expanded through continuous research.<br \/>\nIt has been discovered that crosslinking is also effective for keratitis.  <\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Origin of PACK-Crosslinking  <\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Crosslinking mainly uses riboflavin (vitamin B2) and UV radiation.<br \/>\nThe use of both components has already proven effective in other areas outside of human medicine: <\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduce bacteria in swimming pools  <\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduce bacteria in blood transfusions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Minimize microorganisms in drinking water  <\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">It has been recognized that riboflavin in combination with UV radiation leads to a reduction in fungi, viruses and bacteria.<br \/>\nThe use of CXL was thus extended to corneal infections. <\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Effect of PACK crosslinking<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">PACK cross-linking stops the reproduction of bacteria, viruses and fungi &#8211; this is achieved by deactivating the genetic material.<br \/>\nThe unwanted microorganisms are exposed to oxidative stress.<br \/>\nAt the same time, the resistance of the corneal tissue to infections is improved.  <\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Areas of application for PACK-Crosslinking  <\/span><\/h2>\n<p><span style=\"font-weight: 400;\">PACK-Crosslinking can be used for various reasons.<br \/>\nA corneal infection is not always caused exclusively by bacteria &#8211; viruses or fungi are often involved.<br \/>\nAn antibiotic does not help here.  <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Sometimes long treatments are carried out &#8211; without success.<br \/>\nMany visits to the doctor and frequent use of medication are the result.<br \/>\nIf it is still unclear which pathogens are involved in the infection, safe treatment is not possible.<br \/>\nWith PACK-CXL, all pathogens are detected in just one treatment.   <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>What is keratoconus?<br \/>\nDr. Victor Derhartunian explains what keratoconus is and what treatment options are available.<br \/>\nRead more&#8230;  <\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[141],"tags":[142],"class_list":["post-27368","post","type-post","status-publish","format-standard","hentry","category-faqs-en","tag-crosslinking-glossary-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/eyelaser.at\/en\/wp-json\/wp\/v2\/posts\/27368","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eyelaser.at\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eyelaser.at\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eyelaser.at\/en\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/eyelaser.at\/en\/wp-json\/wp\/v2\/comments?post=27368"}],"version-history":[{"count":0,"href":"https:\/\/eyelaser.at\/en\/wp-json\/wp\/v2\/posts\/27368\/revisions"}],"wp:attachment":[{"href":"https:\/\/eyelaser.at\/en\/wp-json\/wp\/v2\/media?parent=27368"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eyelaser.at\/en\/wp-json\/wp\/v2\/categories?post=27368"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eyelaser.at\/en\/wp-json\/wp\/v2\/tags?post=27368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}